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American Society of Microbiology ABMM Exam Syllabus Topics:

American Society of Microbiology ABMM Sample Questions:

Question 1

A patient with a history of travel to South America presents with fever, lymphadenopathy, and hepatosplenomegaly. Peripheral blood smear reveals the presence of trypomastigotes. The MOST likely diagnosis is:

A. Leishmaniasis
B. Chagas disease (American trypanosomiasis)
C. African trypanosomiasis (sleeping sickness)
D. Malaria

Question 2

A patient who received a solid organ transplant develops a pneumonia. Bronchoalveolar lavage fluid is positive for a single-stranded RNA virus that can cause giant cell formation with intranuclear and intracytoplasmic inclusions. The MOST likely causative agent is:

A. Human metapneumovirus
B. Parainfluenza virus
C. Respiratory syncytial virus (RSV)
D. Adenovirus

Question 3

A clinical microbiology laboratory is monitoring the emergence of resistance to colistin in Gram-negative bacteria. Resistance to colistin is often mediated by modifications of the bacterial lipopolysaccharide (LPS).
The genetic basis for acquired colistin resistance most commonly involves:

A. Alterations in the outer membrane porin proteins, reducing colistin uptake.
B. Acquisition of genes encoding efflux pumps that specifically target colistin.
C. Production of enzymes that directly inactivate the colistin molecule.
D. Mutations in genes encoding enzymes that modify the lipid A component of LPS.

Question 4

What is considered the "gold standard" for routine monitoring of the lethality of steam sterilization (autoclave) cycles in healthcare facilities?

A. Use of chemical indicator strips placed inside each sterilized pack.
B. Regular use of biological indicators containing spores of Geobacillus stearothermophilus.
C. Daily check of autoclave cycle printouts for correct time, temperature, and pressure.
D. Performing a Bowie-Dick test at the beginning of each day for pre-vacuum sterilizers.

Question 5

A patient with a history of chronic sinusitis develops a severe invasive fungal infection involving the nasal sinuses and extending into the orbit. Tissue biopsy reveals broad, aseptate hyphae with irregular branching.
The patient is diabetic and acidotic. The MOST likely causative organism belongs to the genus:

A. Aspergillus
B. Mucor or Rhizopus
C. Fusarium
D. Scedosporium

Solutions: